Optimizing CHO Processes in Bioreactors

The supply of nutrients and the removal of by-products to and from the cell culture affect cell density and viability, the duration of the bioprocess and, as a result, product titer, yield and cost. Therefore, optimizing nutrient supply is critical throughout the bioprocess - for batch, fed-batch, continuous and perfusion culture.

Considering upstream operations such as supplying substrate for cell culture feeding, maintaining optimal growth conditions in fermentation, or cell separation and product isolation in harvesting, the implementation of high accuracy ultrasonic flow meters offers a number of advantages for the upstream process.

Non-contact clamp-on flow meters can be used to automatically measure and dispense culture media – time- and volume-controlled. Thus, flow meters are a cost-efficient and convenient alternative for laboratory balances. Real-time data acquisition of critical process parameters allows seamless monitoring of the bioreactor media, allowing automatic adjustments of the feeding rate at any time.

Non-contact clamp-on flow meters enable precise control and optimization of process parameters at all stages of the upstream bioprocess, resulting in improved efficiency and product quality.

Real-time flow measurement and air bubble detection are performed continuously during the process, enabling constant parameter monitoring to enhance accuracy and efficiency.

• Improving automation and control through precise flow and volume measurement data
• Increasing material and energy efficiency through optimized process control
• Encouraging continuous processing, leading to time, space and cost savings
• Contamination-free measurement thanks to non-invasive ultrasonic technology
• Possibility of implementing Pharma 4.0 concepts thanks to fast response times and modern interfaces

Benefit from our flow meters and air bubble detectors!

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